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Symptoms of Vitamin B12 Deficiency Vitamin B12 deficiency results in symptoms common to a variety of disorders, so blood work and other diagnostic testing may be necessary to rule out other problems

These alterations in the composition or quantity of the NFB dimer have been found to alter downstream target gene expression, contributing, in some cells, to increased expression of pro-inflammatory genes and a pro-apoptotic environment (170, 197, 275)

Clinical practice guidelines should be updated to emphasize clinical diagnosis over surgical confirmation for typical presentations